Tylenol with Codeine package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Tylenol 3 and 4 differ mainly in codeine dose. Learn how that affects pain relief, side effects, and which one doctors typically prescribe. The plasma half-life is 1.25 to 3 hours, but may be increased by liver damage and following overdosage. Elimination of acetaminophen is principally by liver metabolism (conjugation) and subsequent renal excretion of metabolites. Tylenol number 3 is an effective, short-term option for managing pain. Explore its uses and side effects, as well as how the medication compares to Vicodin here. Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including serious liver damage. Tylenol 3 is a prescription painkiller that combines acetaminophen with codeine. Learn its side effects, dosages, and risk of addiction and dependence. Overview: Acetaminophen/codeine is used to treat certain types of pain. It reduces pain signals and changes how your body feels pain. Common side effects include constipation and feeling sleepy or. What is Tylenol with Codeine 3? Tylenol with Codeine 3 is a combination medicine used to relieve moderate to severe pain. Tylenol with Codeine 3 may also be used for purposes not listed in this medication guide. Tylenol with Codeine (acetaminophen / codeine), also known as Tylenol 3, is a combination opioid medication. Both acetaminophen and codeine treat mild-to-moderate pain by blocking pain signals in the body. Medscape - Indication-specific dosing for Tylenol with Codeine, Tylenol 3, Tylenol 4 (codeine, acetaminophen), frequency-based adverse effects, comprehensive interactions.